CONICET: Investigador Principal

DQIAyQF – FCEyN – UBA / INQUIMAE

Licenciatura en Química, Fac. Cs. Exactas y Naturales, Universidad de Buenos Aires, 1992

Doctorado en Química, Departamento de Química Orgánica, Fac. Cs. Exactas y Naturales, Universidad de Buenos Aires, 1997

Postdoc: Instituto Max Planck de Radioquímica, Alemania, 1999-2001

Áreas de interés:

• Biofisicoquímica

• Química Bioinorgánica

• Metaloproteínas

• Transferencia Electrónica

• Espectroscopia y Espectroelectroquímica Raman

Publicaciones seleccionadas:

• Specific methionine oxidation of cytochrome c in complexes with zwitterionic lipids by hydrogen peroxide: potential implications for apoptosis
  D. A. Capdevila, W. A. Marmisollé, F. Tomasina, V. Demicheli, M. Portela, R. Radi, D. H. Murgida
  Chem. Science 2015, 6, 705-713

• Reversible Switching of Redox Active Molecular Orbitals and Electron Transfer Pathways in CuA Sites
  Zitare, U., Álvarez-Paggi, D., Morgada, M. N., Abriata, L. A., Vila, A. J., Murgida, D. H.
  Angew. Chem. Int. Ed. 2015, 54, 9555-9559

• Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
  D. Capdevila, D. Álvarez-Paggi, M. A. Castro, V. Tórtora, V. Demicheli, D. A. Estrín, R. Radi, D. H. Murgida
  Chem. Comm. 2014, 50, 2592-2594

• The role of protein dynamics and thermal fluctuations in regulating cytochrome c / cytochrome c oxidase electron transfer
  D. Álvarez-Paggi, U. Zitare, D. H. Murgida
  BBA-Bioenergetics 2014, 1837, 1196-1207

• Electrostatically-driven second sphere ligand switch between high and low reorganization energy forms of native cytochrome c
  D. Alvarez-Paggi, M. A. Castro, V. Tórtora, L. Castro, R. Radi, D. H. Murgida
  J. Am. Chem. Soc. 2013, 135, 4389-4397

• Native CuA Redox Sites are Largely Resilient to pH Variations within Physiological Range
  D. Alvarez-Paggi, L. A. Abriata, D. H. Murgida*, A. J. Vila
  Chem. Comm. 2013, 49, 5381-5383

• Alternative ground states enable pathway switching in biological electron transfer
  Abriata L. A., Álvarez-Paggi D., Ledesma G. N., Blackburn N. J., Vila A. J., Murgida D. H.
  Proc. Natl. Acad. Sci. USA 2012, 109, 17348-17353

• Molecular Basis of Coupled Protein and Electron Transfer Dynamics of Cytochrome c in Biomimetic Complexes
  Alvarez-Paggi, D., Martín, D. F., De Biase, P. M., Hildebrandt, P., Martí, M. A., Murgida, D. H.
  J. Am. Chem. Soc. 2010, 132, 5769-5778

• Direct Observation of the Gating Step in Protein Electron Transfer: Electric Field Controlled Protein Dynamics
  Kranich, A., Ly, H. K., Hildebrandt, P., Murgida, D. H.
  J. Am. Chem. Soc. 2008, 130, 9844-9848

• Disentangling interfacial redox processes of proteins by SERR spectroscopy
  Murgida, D. H., Hildebrandt, P.
  Chem. Soc. Rev. 2008, 37, 937-945

• The Chromophore Structural Changes in the Photocycle of Phytochrome: a Combined Resonance Raman Spectroscopic and Quantum Chemical Approach
  Mroginski, M. A., Murgida, D. H., Hildebrandt, P.
  Acc. Chem. Res. 2007, 40, 258-266

• Midpoint Potentials of Hemes a and a3 in the Quinol Oxidase from Acidianus ambivalens are Inverted
  Todorovic, S., Bandeiras, T. M., Sousa, F. L., Pereira, M. M., Texeira, M., Hildebrandt, P., Murgida, D. H.
  J. Am. Chem. Soc. 2005, 127, 13561-13566

• Electron Transfer Processes of Cytochrome c at Interfaces. New Insights by Surface-Enhanced Resonance Raman Spectroscopy
  Murgida, D. H., Hildebrandt, P.
  Acc. Chem. Res. 2004, 37, 854-861

• Proton-Coupled Electron Transfer of Cytochrome c
  Murgida, D. H., Hildebrandt, P.
  J. Am. Chem. Soc. 2001, 123, 4062-4068.

Docencia:

• Grado: Qca. Gral. e Inorgánica I

• Optativa grado y post-grado: Tópicos de Fisicoquímica en Sistemas Biológicos